مجله دیابت و متابولیسم ایران
سال بیست و دوم شماره 1 (پیاپی 104، فروردین و اردیبهشت 1401)

The aging process is usually accompanied by a decrease in the function of the body's systems and physiological capacity, along with an increase in susceptibility to diseases, especially metabolic syndrome. This study looked at the effect of eight weeks of resistance training on levels of Irisin, IL-15, CRP, and Cholesterol in elderly men with metabolic syndrome.

The statistical population was elderly men in Khorramabad, of whom 18 were selected and randomly divided into two experimental groups and control (65/2±2/2, 65/4±2/1). The exercise program included leg presses, chest presses, row movements, bending the knees, head, back of the arm, opening of the knees and front of the arm. The above program started with 30% of a maximum repetition and reached 50% of a maximum repetition at the end of the eighth week. Blood samples were taken 48 hours before and after the training sessions. Correlated t-test and independent t-test were used to examine the research data. The level of significance was also considered (P<0.05).

Eight weeks’ resistance exercise significant increase in Irisin (P=0.01) and interleukin-15 (P=0.007), as well as a significantly decreased levels of CRP (P=0.007) and total cholesterol(P=0.02) in elderly men with metabolic syndrome.

Finding non-pharmacological solutions to improve metabolic indicators is very important. Based on the results of research, doing resistance exercises is recommended as a low-cost and non-pharmacological solution for the treatment of metabolic syndrome in elderly men.

The aim of this study was to evaluate the effect of eight weeks of endurance training and Empagliflozin consumption on inflammatory markers and their relationship with heart structure and function of diabetic male Rats.

40 male Wistar rats were randomly divided into five groups: healthy control, diabetic control, diabetic + empagliflozin, diabetic + endurance training and diabetic + endurance training + empagliflozin. The groups were anesthetized and their cardiac function and TNF-α and TGF-β indices were evaluated by one-way ANOVA and Pearson correlation tests after performing the training protocol and receiving medication.

There were significant differences in left ventricular end systolic thickness (P = 0.011), left ventricular end systolic volume (P = 0.008), TNF-α (P = 0.014) and TGF-β (P = 0.001) was observed between the research groups. Also, there was a significant negative relationship between TGF-β with body weight, heart fiber shortening percentage and injection fraction and a significant positive relationship with glucose levels, left ventricular end systolic thickness and left ventricular end systolic volume. In addition, a significant negative correlation was observed between TGF-β and the injection fraction (P≤0.05).

Aerobic exercise seems to improve the inflammatory status, structure and function of diabetic heart tissue beyond the dual effect of Empagliflozin.

Diabetic disorders can lead to muscle atrophy. The aim of this study was to investigate the combination of resistance training and endothelial progenitor cell injection on the expression of horseshoe muscle atrophy factor in diabetic rats.

30 rats (6 weeks old weighing 200 20 200 g) were randomly divided into five groups: healthy baseline, control diabetic, trained diabetic, non-trained diabetic by endothelial progenitor cell injection, diabetic trained by simultaneous injection Endothelial progenitor cells were divided. Heat 25 was measured by Western blotting to evaluate changes in protein expression. Data were analyzed by two-factor analysis of variance test by SPSS software version 19 at a significance level of α≥ 5%.

In this study, 6 weeks of resistance training had no significant effect on the expression of heat shock protein 25. But injection of endothelial progenitor cells resulted in a significant increase in the expression of heat shock protein 25. The interactive effect of resistance training and progenitor cell injection on heat shock protein 25 was not significant, in other words, there was no significant superiority over training and injection at the same time as training or injection alone.

Based on the findings of this study, it can be stated that injection of endothelial progenitor cells can improve muscle wasting but resistance training alone was not effective. Also, the combination of these two strategies was not superior in reducing the complications of atrophy in diabetic rats.

Obesity has been recognized as one of the top 10 health problems by the World Health Organization. The purpose of the present study was to the effect of aerobic training on atrogin, eotaxin and IL-10 indices in obese women.

The present applied research was a quasi-experimental study in which 30 obese women aged 30-45 years were selected by available method from South Tehran Azad University (2016-2017) and randomly divided into two groups of aerobic exercise and control. 24 hours before the start of training, the individual characteristics of the subjects and the research variables (atrogen, eutoxin and IL-10) were measured in blood tissue, then the subjects of the experimental group had their training program for 8 weeks, 3 They performed one session per week and each session lasted 45-60 minutes under the supervision of a researcher. Dependent and independent t-test was used to analyze the data.

Due to the lack of differences in pre-test scores, it was found that the groups were identical. It was also found that 8 weeks of aerobic exercise had a significant effect on the levels of eutoxin, atrogen and interleukin-10 in obese women (p = 0.001)

According to the research results, it is recommended that obese women exercise aerobically. Use to reduce the negative effects of obesity.

Chronic hyperglycemia is associated with an increase in cellular damage due to oxidative stress and increases insulin resistance and also increases in p53 and p16 beta cells, leading to the induction of senescence in pancreatic insulin-secreting cells. The aim of this study was the effect of eight weeks of aerobic exercise on the expression of senescence proteins P53 and P16 in the pancreatic tissue of diabetic mice.

In this study, 15 NMRI mice (26.3 ±3.22 g) were divided into three groups randomly: healthy control, diabetic control and diabetic exercise. They were diabetic by HFD for 5 weeks and intraperitoneal injection of STZ. The aerobic training protocol (50-60% Vmax) was 5 days a week for 8 weeks. After anesthesia, blood and pancreatic tissue were removed. Insulin resistance, P53 and P16 protein concentrations in pancreatic beta cells were measured. Data were analyzed by ANOVA with a significance level of p <0.05.

According to the results of eight weeks of aerobic exercise by mice diabetic type 2, a significant decrease in insulin resistance (p = 0.005), protein concentrations of P53 (p = 0.002) and P16 (p = 0.010) in pancreatic tissue was observed.

Aerobic exercise may improve insulin sensitivity and delay cellular senescence due to diabetes by reducing cell senescence factors such as P53 and P16 in beta cells. Therefore, this type of exercise can be considered as a therapeutic approach to improve the condition of these patients.

The aim of the present study was to investigate the simultaneous effect of resistance training and stem cell injection on the levels of some indicators of skeletal muscle apoptosis in STZ-induced diabetic male rats.

In this study, 30 rats were randomly divided into 5 groups. Rats in the diabetic group and the diabetic group + stem cell injection had a total of 17 sessions of resistance training for 5 weeks. The training period for rats with this type of training was 3 days, which was done 48 hours before STZ injection. Western blotting was used to evaluate the changes in Caspase7 and caspase3. The data were analyzed using two-factor analysis of variance test with SPSS software version 19 at a significance level of α≤ 5%.

The results of the present study showed that there was no significant difference between the mean of caspase3 in the resistance training group with simultaneous injection of stem cells and the training group. Also, resistance training with simultaneous injection of endothelial stem cells, compared to resistance training or injection alone, led to a significant reduction in Caspase7 expression in skeletal muscle tissue of diabetic rats.

Based on the results of this study, it can be stated that resistance training or injection of endothelial progenitor cells can stimulate apoptosis in skeletal muscle.